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Katherine Marie Heigl was born in Washington, DC, on November 24, 1978, to Nancy and Paul Heigl. Her family moved to New Canaan, Connecticut, when Katherine was younger, so she spent the majority of her childhood there, and attended to New Canaan High School. Katherine is the youngest of four kids (elder siblings: John, Jason and Meg). Tragically, her brother Jason died in a car accident back in 1986. This drastic experience gave Katherine a greater perspective and appreciation for life. She’s promoting the importance of organ donatio since she’s a celebrity.

Katherine’s career started at the age of nine, with a contract at Wilhelmina, a renowned international modeling agency after her aunt sent a few pictures, she took of Katie for the promotion of her own hair care product, to a few modeling agencies. Shortly after her parents signed the contract Katherine made her debut in a magazine advertisement, followed by a tv commercial for Cheerios breakfast cereal.

After years of modeling, she started acting in 1992. Her first movie project was called That Night, which starred Juliette Lewis and C. Thomas Howell. With this movie she realized her passion for acting. In 1993, she played a role in Steven Soderbergh‘s King of the Hill, right before she got her first leading role in My Father the Hero a year later. In the following 2 years she made appearances in Under Siege 2: Dark Territory (1995) and Disney’s Wish Upon a Star (1996).

Her parents devorced in 1996, and Katherine graduated form High School in 1997. Since this time her mother’s managing her career. In the following two years she filmed Stand-ins (1997), Prince Valiant (1997), The Tempest (1998), Bug Buster (1998) and Bride of Chucky (1998).

In 1999, Katherine started to play on television series as she got the role of Isabel Evans on Roswell. She played this character for 61 episodes. During she filmed that series, Katie and her mother made an appearances in an episode of the Sci-Fi TV talk show Crossing Over with John Edward (1999), during which she spoke with John Edward, a psychic medium, about her late brother, Jason. She also played Shelley, in the movie Valentine (2001), and a role in 100 Girls (2000).

In the spring of 2001, Katherine accepted a role in NBC’s Critical Assembly (2003), a two-hour original television thriller. Katherine and Kerr Smith (“Dawson’s Creek” (1998)) co-starred as brilliant and politically concerned college students who build a nuclear device to illustrate the need for a change in national priorities, but are betrayed by a fellow student when the bomb ends up in the hands of a terrorist. Unfortunately, the telefilm, directed by Eric Laneuville, written by Tom Vaughan, and based on the best-seller The Seventh Power by James Mills, was shelved when its storyline was deemed too close for comfort to the events of September 11, 2001. It was eventually broadcast in 2003.

In 2002, Katherine signed on for representation in all areas with the William Morris Agency, one of the biggest and most prestigious agencies in the entertainment industry and was then managed by Norman Aladjem at Paradigm Agency and being managed by Nancy Heigl and Stephanie Simon and Jason Newman at Untitled Entertainment.

Katherine appeared in a episode of The Twilight Zone in 2002, and did a psychological thriller called Descendant a year later. In 2005, she took part in the second part of the prequel Romy and Michele’s High School Reunion (1997) called Romy and Michele: In the Beginning.

She landed her breaking-role in 2004 on the television series Grey’s Anatomy, where she played Dr. Isobel “Izzie” Stevens for 6 years, in 109 episodes. After she reportedly did not show up for work when she was supposed to, and she and Shonda Rhimes, creator of the show, had apparently come to an agreement to release her from her contract immediately. Therefore, Katherine’s last appearance on the “I Like You So Much Better When You’re Naked” episode of Grey’s Anatomy is also her final appearance on the season. Heigl said that her departure was not about advancing her film career but that she wanted to focus more on her family.

During her time on Grey’s Anatomy, she filmed two movies: Knocked Up (2007), 27 Dresses (2008) & The Ugly Truth (2009).

After she ended TV Shows she headed back to movies with her leading-roles in Killers and in Life As We Know It, both filmed in 2010.

On December 23rd, 2007, Katherine married her longtime boyfriend, musician Josh Kelley after they became engaged in June 2006. In September 2009 they’ve adopted a baby girl from South Korea, they named her Nancy Leigh (after Heigl’s mother and sister, respectively), nicknamed Naleigh. Naleigh needed a open heart surgery as she were born, blessedly everything went well and she’s healthy now. In April 2012, Naleigh became a sister named Adalaide Marie Hope, Katherine and Josh adopted her, too.